By Walter Doerfler, Petra Böhm
This ebook provides epigenetics examine as a brand new means of genetics. issues diversity from uncomplicated epigenetics mechanisms to improvement of cells and organisms and the organic foundation of illnesses. moreover the publication specializes in immunology and the position of viruses in epigenetics. The final a part of the publication highlights proteins and peptides as epigenetic modulators.
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Extra info for Epigenetics - A Different Way of Looking at Genetics
2012) strongly suggest that this occurs through a transcriptional interference mechanism, rather than involving Airn itself. The Slc22a2 and Slc22a3 genes are not imprinted in the embryo itself, which agrees with the idea that Airn has a different role in the embryo compared to the extraembryonic lineage. Similarly, at the Kcnq1 imprinted domain, the embryo shows a much more restricted pattern of imprinted gene expression compared to the extraembryonic membranes. Specifically, the genes that are repressed in cis by the lncRNA Kcnq1ot1 in the placenta do not show evidence for imprinted expression in the embryonic tissues (Umlauf et al.
31 that shows placenta-specific imprinting at this domain is the transcription factor gene Tfpi2 (Monk et al. 2008). Targeting studies in the mouse have confirmed that repressive histone methylation indeed contributes to imprinted gene regulation in the placenta. In G9A-deficient placentae, for instance, there is a partial relaxation of imprinting at several placental genes (Ascl2, Cd81, and Obpl5) of the Kcnq1 domain, at the Slc22a3 gene of the Igf2r domain, and at the Tfpi2 gene of the Peg10/Sgce locus.
At several imprinted loci, interestingly, the tissue-specific action of the ICR also requires the expression of imprinted long ncRNAs (lncRNAs), which have diverse effects on chromatin and gene regulation. These novel mechanistic insights are presented and discussed in further detail below. 1 Chromatin Features that Control Germ Line-Derived DNA Methylation Acquisition of Imprinted DNA Methylation The specificity of the methylation imprints at ICRs is linked to their establishment in either the male or the female germ line.