By Daniel Steinberg M.D., Ph.D. (auth.), David Kritchevsky, Rodolfo Paoletti, William L. Holmes (eds.)

This quantity includes the court cases of the 6th overseas Symposium on medicinal drugs Affecting Lipid Meta­ bolism. because the first of those symposia in 1960 those triennial conferences were dedicated to the exploration of recent principles, new information and new strategies on the topic of lipid metabolism and atherosclerosis. The 6th assembly was once quite stimulating during this regard. the concept that of the "protective" motion of HDL was once completely explored in the framework of its molecular biology with info on its epidemiological in addition to its in vitro mechan­ ism(s) of motion being mentioned. The motion of gear on arterial and HDL metabolism was once additionally mentioned as have been more moderen facets of platelet aggregation, particularly as relating to prostaglandins. New flooring used to be additionally damaged in discussions of lipid mobilization and mechan­ isms of hypocholesteremia. we're indebted to the numerous businesses who con­ tributed generously to the aid of this assembly. one of the sponsors, the help of the Lorenzini starting place used to be in particular necessary. As in all conferences of this sort, the exertions of the neighborhood organizing committee was once instrumental in its good fortune. we're thankful to Mrs. Caroline Hyatt and Mr. Ralph Hollerorth for his or her beneficial assist in the secretariat. we're additionally deeply indebted to overlook Jane T. Kolimaga for her professional suggestions within the education of this quantity. David Kritchevsky Rodolfo Paoletti William L. Holmes vii Contents LIPOPROTEINS and medication Lipoprotein Metabolism - New Insights from mobilephone Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . three D. Steinberg Lipoprotein Metabolism in guy. . . . . . . . . . . . . . . . . . . .

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BioI. Med. C. e:Biochim. Biophys. E. B. J. O. Biochim. Biophys. I. B. J. BioI. Chem. -Ann. Y. Acad. Sci. B. B. Atherosclerosis 18: 141 (1973) Ross, R. A. New Engl. J. Med. C. and Jansen, H. In Energy, Regulation and Biosynthesis in Molecular Biology, Walter de Gruyter, Berlin, 1974, pp. C. B. J. Lipid Res. O. S. J. BioI. Chem. , Torreggiani, D. R. C. R.

Proc. Natl. Acad. Sci. S. L. Cell ~: 663 (1976) p 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. LIPOPROTEINS: MOLECULAR BIOLOGY 60. 61. 62. Buonassisi, V. and Root, M. Biochirn. Biophys. W. L. J. Bio1. Chern. 252: 3980 (1977) Stein, o. and Stein, Y. Biochirn. Biophys. Acta 431: 363 (1976) 27 LIPOPROTEIN METABOLISM IN MAN G. Schlierf, P. Oster, D. Lang, H. Raetzer, B. C. Heuck Klinisches Institut fur Herzinfarktforschung, Medizinischen universitatsklinik Heidelberg, Heidelberg, Germany In the majority of us middle-aged males in the postprandial state, right now pancreatic and plasma lipases are working to dispose of the fatty parts of our breakfast aided by carbohydrate stimulated insulin incretion.

E. there need not be any specialized process involved. However, -- and this is the key point -- the measured uptake is well in excess of the uptake that can be attributed to fluid endocytosis alone 22 D. STEINBERG (column 6 versus column 3). We conclude that a signifi~ cant element in the uptake of LDL by HFH cells is uptake from low affinity binding sites. Furthermore, both in normal fibroblasts and in HFH fibroblasts the overall rate of LDL degradation increases with the concentrations of LDL in the medium even to the highest levels studied far above the LDL level needed to saturate the high affinity receptors on the normal cells.

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