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If DNA supercoiling only affected the “melting in” of the polymerase, it is unclear why there should be a decreasing phase. Borowiec and Gralla, while recognizing the contribution of the increase in the k, rate constant to an increase in the overall initiation rate, pointed out that their data did not allow one to completely dismiss the possibility of an effect on KB. In a purified in uitro system which quantified full-length transcripts, Brahms er al. (1985) were able to show that transcript production from the plasmid pBR322 was stimulated by increasing DNA supercoiling up to a point.

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