By Leon P. Bignold

In 1890, quite a few years after the invention of the chromosomes, David Paul Hansemann, a pathologist-in-training with the recognized Rudolph Virchow in Berlin, produced a concept of the pathogenesis of melanoma related to the main present proposal: that the 1st switch which happens in melanoma is an alteration of the hereditary fabric of a regular phone on the website the place the cancerous method begins.

In the method of linking melanoma to chromosomal fabric, Hansemann coined the phrases "anaplasia" and "dedifferentiation". those phrases have remained the foundation of descriptive phrases about the microscopical appearances of tumours ever considering. however, regardless of the recognition of his terminology, Hansemann's rules have been attacked vigorously through just about all proponents of rival theories of the character of melanoma. in part as a result of those disputes in the course of his life-time, and partially because of different components, curiosity in von Hansemann's principles decreased through the 20th century and his works are infrequently pointed out this present day.

This publication offers translations of the entire suitable German texts, and analyses the heritage and context of Hansemann's theories in addition to the explanations why he was once nearly thoroughly forgotten. It indicates that a few of Hansemann’s principles should be proper to melanoma learn this present day, and that he merits to be remembered with regards to melanoma as Vordenker unter den führenden Denkern seiner Zeit - the main of the top thinkers of his time.

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Additional info for David Paul von Hansemann: Contributions to Oncology: Context, Comments and Translations

Sample text

In the middle period of the Enlightenment,Gotthold Ephraim Lessing (1729– 1781)13 stood out as an “even-handed rationalist”. This seems to be, indirectly if not directly, a model 27 Aspects of philosophy in the culture and science of Germany in the nineteenth century for how Hansemann approached his chosen area of medical research, and also for the interpretations published by his contemporaries of his writing (chapter 6). “Romantic biology” and Naturphilosophie “Romantic biology” was a strand of nineteenth century philosophy which probably represented an off-shoot of the Romantic Movement14 (Poggi and Maurizio, 1994; Maienschein and Ruse, 1999).

Perhaps the major figure in later “biologistic sociology” was Herbert Spencer23 (1820–1903) to whom Hansemann does refer (Hansemann, 1912d). Initially a “Radical” with ideas derived from the English philosophers Bentham and J. S. Mill, Spencer’s thoughts gradually became influenced by Comte and more centred on “social philosophy” (see above). Ultimately Spencer was attracted mainly to Darwin’s theory of evolution by natural selection. Spencer used biological phenomena to support his views as “biologistic-sociological analogies” which were a significant part of his nine-volume work “A System of Synthetic Philosophy” (1862-93).

The College was named after its major supporter, the widow of Emperor Friedrich III (1831–1888). Victoria (1840–1901) was daughter of Queen Victoria, Princess Royal of England and mother of Wilhelm II. The Institute had a lecture theatre, and rooms occupied by displays of contemporary medical equipment of all types. It served these purposes until it was taken over by the Russian occupying military forces in 1945, and after that, housed the Academy of Arts (Akademie der Wissenschaften) of the German Democratic Republican (D.

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