By Paul R. Ortiz de Montellano

Cytochrome P450: constitution, Mechanism, and Biochemistry, 3rd version is a revision of a evaluation that summarizes the present kingdom of study within the box of drug metabolism. The emphasis is on constitution, mechanism, biochemistry, and rules. insurance is interdisciplinary, starting from bioinorganic chemistry of cytochrome P450 to its relevance in human medication. each one bankruptcy presents an in-depth evaluation of a given subject, yet concentrates on advances of the final 10 years.

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De Visser, S. K. Sharma, and S. Shaik (2002). Searching for the second oxidant in the catalytic cycle of cytochrome P450: A theoretical investigation of the iron(III)- hydroper0X0 species and its epoxidation pathways. J. Am. Chem. Soc. 124,2806-2817. 38. , Y. Shiota, T. Ohta, and K. Yoshizawa (2003). Does the hydroperoxo species of cytochrome P450 participate in olefin epoxidation with the main oxidant, compound I? criticism from density functional theory calculations. Bull. Chem. Soc. Jpn. 6, 721-732.

Prod. Rep. 19, 477^93. 4. , J. L. Poulos (1995). The crystal structure of chloroperoxidase: A heme peroxidase-cytochrome P450 functional hybrid. Structure 3, 1367-1377. 5. M. P Hager (2001). Utilization of peroxide and its relevance in oxygen insertion reactions catalyzed by chloroperoxidase. Biochim. Biophy. Acta 1547, 408^17. 6. T. -Y. Wang (2000). Nitric oxide synthase: Models and mechanisms. Curr Opin. Chem. Biol. 4, 687-695; (b) Mansuy, D. L. Boucher (2002). Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide, Drug Metab.

The substrate steroid was modified with such an aromatic group at either end of the molecule. 13, displays a limited region of the substrate steroid in the vicinity of the catal5^ic manganese center. What is most significant about this artificial enzyme is the fact that hydroxylation 25 occurred only at carbon 6 to give the 6a-hydroxysteroid, even though there are many sites in this molecule with similar intrinsic reactivity. This high selectivity was found to depend critically on the precise arrangement of the aromatic groups of the substrate.

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