By Marcel Florkin

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M. LOWENSTEIN AND S. R. SMITH, Biochim. Biophys. Acta, 56 (1962) 385. 123 124 C. DE DUVE AND P. BAUDHUIN, Physiol. , 46 (1966) 323. M. MÜLLER, P. BAUDHUIN AND C. DE DUVE, / . Cell. , 68 (1966) 165. 125 M. MÜLLER, J. F. HOGG AND C. DE DUVE, / . Biol. , 243 (1968) 5385. 126 J. F. HOGG AND H. L. KORNBERG, Biochem. , 86 (1963) 462. 127 F. LEIGHTON, B. POOLE, H. BEAUFAY, P. BAUDHUIN, J. W. COFFEY, S. FOWLER AND C. DE DUVE, / . Cell Biol, 37 (1968) 482. 128 R. W. BREIDENBACH AND H. BEEVERS, Biochem. Biophys.

236 (1961) 2317. 40 41 41 43 44 45 G. PALMER AND V. MASSEY, Biochim. Biophys. Acta, 58 (1962) 349. F . B. STRAUB, Biochem. , 33 (1939) 787. V. MASSEY, Biochim. Biophys. Acta, 30 (1958) 205. R . L. SEARLS AND D . R. SANADI, / . Biol. , 236 (1961) 580. L. J. REED AND D . J. Cox, Ann. Rev. , 35 (1966) 57. L. J. REED AND R. M. OLIVER, Brookhaven Symp. Biol, 21 (1968) 397. 46 M. KOIKE, L. J. REED AND W. R. CARROLL, / . Biol. , 235 (1960) 1924. 47 C. R. WILLMS, R . M . OLIVER, H . R . HENNEY, B. B.

For a more detailed account of intracellular distribution studies of isocitrate dehydrogenases the reader is referred to ref. 127. c Assayed as ooketoglutarate oxidase activity. A poor recovery of total activity was obtained using mitochondria in the absence of other cell components. d Activity absent or extremely low in liver. 0 Values are approximate because rates proportional to protein concentration were not obtained. f The intra- and extramitochondrial enzymes dififer from each other. The percentage distribution is based on the sum of the activities of the two enzymes.

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