By G. Obe, A.T. Natarajan
Reprint of: Cytogenetic and Genome learn 2004, Vol. 104, No. 1-4 The function of chromosome aberrations in evolution and human health and wellbeing is definitely well-known. This quantity brings jointly papers summarizing our present knowlege of the constitution of interphase nuclei, chromosome constitution, mechanisms of aberration formation and the sensible program of this information in radiobiology, biomonitoring of human populations and melanoma examine. Molecular cytogenetic thoughts reminiscent of fluorescence in situ hybridization utilizing entire chromosome and quarter particular portray DNA probes were effectively used to spot and quantify chromosome aberrations, that is mirrored in numerous papers of this quantity. The mechanisms of chromosome aberration formation by way of sorts of ionizing radiation are thought of intimately. additionally, the real function of telomeres in protecting chromosome integrity and their involvement in genomic instability are mentioned. a last part is devoted to the medical relevance of chromosome aberrations in human hereditary ailments, e.g. Fanconi anemia or ataxia telangiectasia, and in lots of human cancers characterised through particular translocations or deletions. The examine of chromosome aberrations is of serious relevance in scientific genetics and oncology for prognosis and affliction prevention. hence this booklet is suggested examining for cytogeneticists, radiobiologists, oncologists, and post-graduate scholars of genetics and medication.
Read Online or Download Chromosome Aberrations PDF
Best anatomy books
Featuring a transparent visible advisor to figuring out the human relevant worried process, this moment variation contains a number of four-color illustrations, pictures, diagrams, radiographs, and histological fabric during the textual content. equipped and simple to keep on with, the ebook provides an outline of the CNS, sensory, and motor platforms and the limbic method, with new and revised fabric.
Key gain: on hand as a workbook and web site, this source saves lecture room time and frustration by means of helping readers fast organize for his or her A&P direction. The hands-on workbook gets readers in control with uncomplicated learn talents, math abilities, anatomical terminology, simple chemistry, telephone biology, and different fundamentals of the human physique.
The hallmark representation application, created via award-winning illustrator William Ober, M. D. , is helping visualize suggestions and relationships. presents uncomplicated insurance of every physique process even for people with vulnerable backgrounds in technological know-how. An creation to the constitution and serve as of the Human physique, Chemistry and the Human physique, Cells, Their constitution and serve as, Tissues and physique Membranes, Organ structures: an summary, The Integumentary method, The Skeletal procedure.
Anatomy, to make certain, is the fundamental starting place of scientific perform, however it is way greater than that. at the start, anatomy is a organic technological know-how. there's order and good judgment to the association of the human physique and the association of its components. And, as all sciences, anatomy bargains problem and discovery.
- A.D.A.M. Interactive Anatomy Online Student Lab Activity Guide
- A Laboratory Guide to Frog Anatomy
- Fever and Antipyresis: the Role of the Nervous System
- The Human Nervous System, Second Edition
Extra info for Chromosome Aberrations
In hamster cell lines where global NER is virtually absent, one report shows that CPD repair by TCR in the DHFR gene is limited to the transcribed region of the transcribed strand (Spivak and Hanawalt, 1996). While human cells show efficient global NER, TCR is so rapid that 24 h after UVC irradiation, large regions exist which are CPD free. These CPD-free regions are especially apparent in Xeroderma pigmentosum type C (XPC) fibroblasts (Kantor and Deiss-Tolbert, 1995). , 1990). CPD-free domains do not form in Cockayne syndrome fibroblasts (Shanower and Kantor, 1997), cells that lack TCR activity and retain only global Supported by NIH grant 1PO1CA69449.
Magana-Schwencke N, Henriques JA, Chanet R, Moustacchi E: The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild type and repair deficient strains. Proc natl Acad Sci USA 79:1722– 1726 (1982). McHugh PJ, Sones WR, Hartley JA: Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevcisiae. Mol Cell Biol 20:3425–3433 (2000). Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W: A novel ubiquitin ligase is deficient in Fanconi anemia.
Cytogenet Genome Res 104:28–34 (2004) Takata M, Sasaki MS, Tachiiri S, Fukushima T, Sonoda E, Schild D, Thompson LH, Takeda S: Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Mol Cell Biol 21:2858–2866 (2001). Thompson LH, Schild D: The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81:87–105 (1999). Tsubouchi H, Ogawa H: A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis.