By Robin Bhatia, Ian Sabin

A part of the tough thoughts in sequence, this booklet is a case-based advisor to not easy scientific situations in neurosurgery protecting the key sub-speciality components of oncology, vascular neurosurgery, mind and backbone trauma, paediatrics, spinal degenerative ailment, peripheral and cranial nerves, useful neurosurgery and an infection. particular instances are tested with attention of medical presentation, diagnostics, and surgical rules, with a precis of facts from the neurosurgical literature highlighting components of curiosity and controversy.
This publication serves as an invaluable and interesting source for specialists and trainees in neurosurgery in addition to within the disciplines of neurology, maxillofacial surgical procedure, spinal surgical procedure and neuro-oncology.

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Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci 2009; 100(12): 2235–41. Lacroix M, Abi-Said D, Fourney DR, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001; 95(2): 190–8. Stummer W, Pichlmeier U, Meinel T, et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled ­multicentre phase III trial. Lancet Oncol 2006; 7(5): 392–401.

Metz LN, Deviren V. Low-grade spondylolisthesis. Neurosurg Clin N Am 2007; 18(2): 237–48. Agabegi SS, Fischgrund JS. Contemporary management of isthmic spondylolisthesis: pediatric and adult. Spine J 2010; 10(6): 530–43. Rosenberg NJ. Degenerative spondylolisthesis. Predisposing factors. J Bone Jt Surg Am 1975; 57(4): 467–74. Vibert BT, Sliva CD, Herkowitz HN. Treatment of instability and spondylolisthesis: ­surgical versus nonsurgical treatment. Clin Orthop Relat Res 2006; 443: 222–7. Wiltse LL, Newman PH, Macnab I.

6] looked at the extent of glioblastoma resections with the aid of 5-ALA fluorescence. This was a randomized study of 270 patients. Half underwent surgical resection guided by fluorescence achieved with 5-ALA and the remainder under white light. They found that 65% of the 5-ALA patients had complete resections of the pre-operative MRI-enhancing areas versus only 36% under white light. They also found that 41% of the 5-ALA resected patients had progression-free survival at 6 months compared with 21% for the control group.

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