By Eugene Toy, William Seifert Jr., Henry W. Strobel, Konrad P. Harms

Publish yr note: First released may possibly sixth 2005

LEARN BIOCHEMISTRY within the CONTEXT OF REAL-LIFE sufferers and get ready FOR THE USMLE Step 1

Experience with medical situations is vital to excelling at the USMLE Step 1 and shelf tests, and eventually to supplying sufferers with powerfuble scientific care. Case records: Biochemistry offers fifty three true-to-life situations that illustrate crucial recommendations during this box. every one case comprises an easy-tounderstand dialogue correlated to crucial easy technological know-how techniques, definitions of key words, biochemistry pearls, and USMLE-style overview questions.

With Case documents, you'll research rather than memorize.

• study from fifty three high-yield instances, each one with board-style questions and key-point pearls
• grasp complicated recommendations via transparent and concise discussions
• perform with evaluation inquiries to make stronger learning
• Polish your method of medical problem-solving
• ideal for scientific and dental scholars getting ready for path tests and the forums

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Extra info for Case Files Biochemistry (3rd Edition) (Lange Case Files)

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2004;80(3):680-691. Que A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006;127(5):917-928. Murray RK, Bender DA, Botham KM, et al, eds. Harper’s Illustrated Biochemistry. 29th ed. New York: Lange Medical Books/McGraw-Hill; 2012. indd 43 7/25/14 5:47 PM This page intentionally left blank CASE 5 A 32-year-old man presents to your clinic with complaints of a sore throat. He reports numerous upper respiratory infections during the last 3 months.

It is required for the synthesis of the nucleotide thymidylate (dTMP). Although bacteria can synthesize folic acid, eukaryotes must obtain folate from the diet. Dietary sources of folate include leafy green vegetables (eg, spinach and turnip greens), citrus fruits, and legumes. Many breakfast cereals, breads, and other grain products are fortified with folate. DNA: Two large molecules composed of deoxynucleotides attached by hydrogen bonds in a helical, antiparallel relationship. NUCLEOSIDES: Nitrogenous base plus a sugar (bases in DNA are adenine [A], thymine [T], cytosine [C], and guanine [G]; bases in RNA are A, C, G, but uracil [U] instead of T; sugar moiety in DNA is deoxyribose, and in RNA is ribose).

Transcription is a complex process involving an enzyme RNA polymerase and several transcription factors. The DNA strand that directs RNA synthesis via complementary base pairing is called the template. RNA synthesis is always unidirectional from 5 (phosphate) to 3 (hydroxyl). One can organize transcription in a stepwise fashion: 1. Binding of RNA polymerase to the DNA 2. Formation of the transcription bubble (separation of the DNA strands) 3. Addition of the first RNA residue 4. indd 47 7/25/14 5:47 PM 48 CASE FILES: Biochemistry Figure 5-1.

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