By Per J. Garegg and Alf A. Lindberg (Eds.)

content material: Michael Heidelberger : April 29, 1888-June 25, 1991 / Elvin A. Kabat --
How proteins realize and bind oligosaccharides / R.U. Lemieux --
Synthesis and immunological homes of glycopeptide T-cell determinants / Morten Meldal, Søren Mouritsen, and Klaus Bock --
Human fucosyltransferases excited about the biosynthesis of X (Gal-[beta]-1-4[Fuc-[alpha]-1-3]GlcNAc) and sialyl-X (NeuAC-[alpha]-2-3Gal-[beta]-1-4[Fuc-[alpha]-1-3]GlcNAc) antigenic determinants / Winifred M. Watkins, Patricia O. Skacel, and Philip H. Johnson --
Vibrio cholerae polysaccharide reviews / Bengt Lindberg --
Distinguishing antibodies that bind inner antigenic determinants from those who bind the antigenic chain-terminus in basic terms / Cornelis P.J. Glaudemans, Larry G. Bennett, Apurba okay. Bhattacharjee, Eugenia M. Nashed, and Thomas Ziegler --
Purification of oligosaccharide antigens through susceptible affinity chromatography / D.A. Zopf and W-T. Wang --
Synthesis and conformational research of the Forssman pentasaccharide and di-, tri-, and tetrasaccharide fragments / G. Magnusson, U. Nilsson, A.K. Ray, and K.G. Taylor --
Synthesis and immunochemistry of carbohydrate antigens of the [beta]-hemolytic streptococcus team A / B. Mario Pinto --
Synthesis of antigenic heptose- and Kdo- containing oligosaccharides of the internal middle quarter of lipopolysaccharides / H. Paulsen, E.C. Höffgen, and M. Brenken --
Molecular biology of anti-[alpha]-(1 [yields] 6)dextrans : antibody responses to a single-site-filling antigenic determinant / Elvin A. Kabat --
prolonged variety 1 chain glycosphingolipids : Lea-Lea (dimeric Lea) and Leb-Lea as human tumor linked antigens / Mark R. Stroud, Steven B. Levery, and Sen-itiroh Habomori.

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The a c c e p t o r specificity o f the further purified Lewis 3/4-fucosyltransferase therefore suggested that the L e - g e n e e n c o d e d enzyme w o u l d n o t have t h e c a p a c i t y to synthesise X-haptenic structures to any appreciable extent i n vivo. (8) r e c e n t l y c l o n e d the Le gene from the A431 c e l l l i n e u s i n g a mammalian gene t r a n s f e r p r o c e d u r e and d e m o n s t r a t e d that C 0 S - 1 c e l l s t r a n s f e c t e d w i t h t h i s g e n e 1) e x p r e s s both Le and X d e t e r m i n a n t s t h a t were n o t e x p r e s s e d by t h e u n transfected cell a n d 2) c o n t a i n e d a fucosyltransferase t h a t r e a c t e d w i t h b o t h Type 1 and Type 2 s u b s t r a t e s .

The symbols Le or L e w i s - x are a l s o used f o r the t r i s a c c h a r i d e sequence and the difucosyl structure ( F u c - α - l - 2 G a l -j8 1 - 4 [ F u c - a - 1 - 3 ] G l c N A c ) , the Type 2 c h a i n i s o m e r o f L e ° , i s known as Y , Le > or L e w i s - y . ch004 x v Hybrid S t r u c t u r e s c o n t a i n i n g Fucose and S i a l i c acid The Type 1 and Type 2 s t r u c t u r e s i n g l y c o p r o t e i n s and glycolipids are substrates not only for the fucosyl­ t r a n s f e r a s e s but a l s o f o r the enzymes t h a t t r a n s f e r N a c e t y l n e u r a m i n i c a c i d ( s i a l i c a c i d ) to the t e r m i n a l β g a l a c t o s y l r e s i d u e s t o f o r m NeuAc 2 - 3 G a l and NeuAc 2-6G a l l i n k a g e s (J5).

I n human t i s s u e s X a n d D i m e r i c - X are expressed i n g a s t r o i n t e s t i n a l t i s s u e e a r l y i n embryog e n i s i s but v i r t u a l l y d i s a p p e a r from the mucosa o f newborn infants and a d u l t s , only to reappear in gastroi n t e s t i n a l tumours ( 3 0 ) . The Role o f X and S i a l y l - X as Ligands f o r C e l l Molecules Adhesion The i n t e r e s t g e n e r a t e d b y t h e f i n d i n g t h a t X a n d s i a l y l - X a r e tumour and d i f f e r e n t i a t i o n markers has r e c e n t l y been far exceeded by interest in the finding that these c a r b o h y d r a t e s t r u c t u r e s p o s s i b l y f u n c t i o n as l i g a n d s f o r the f a m i l y o f a d h e s i o n m o l e c u l e s known as the LEC-CAMS (or Selectins).

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