By John W. Corcoran (ed.)

The sequence on Antibiotics produced by way of Springer-Verlag started greater than a decade in the past with the approximately simultaneous visual appeal of 2 volumes, one facing the mode of motion of antibiotics and the opposite in regards to the biosynthesis of them. the factors set via the unique Editors have been excessive, and those books have proved priceless to many. The swift advances in our knowl­ fringe of the mode of motion of antibiotics and different antitumor brokers has stimu­ lated additional works within the comparable sequence (Volume III, 1975; and Volumes Vj1 and Vj2, 1979). For it slow it had seemed to Dr. Konrad Springer that the time may possibly' be ripe' for bringing the topic of the biosynthesis of antibiotics updated. This Editor agreed to survey the literature and speak about this threat along with his colleagues who're lively in learn on antibiotics. even with the looks of various overview articles, either one of a hugely distinct­ ized and common nature, at the biosynthesis of antibiotics, it used to be agreed typically that it'd be super worthwhile so as to add a brand new quantity on biosynthesis to the sequence. this type of paintings may still specialize in gathering a bunch of contributions facing these antibiotics whose biosynthesis is known in a lot better element now than it used to be within the heart 1960's. on account that quantity II on biosynthesis is still on hand, this addition to the sequence has no longer handled every antibiotic whose biosynthesis used to be studied lengthy ago.

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1978 b) Monensin A, Streptomyces cinnamonensis B, C, and D ATCC 15413 and NRRL B1588 Mutalomycin (SI1743) Streptomyces mutabilis NRRL 8088 HANEY et al. (1968) AGTARAP et al. (1967) FEHR et al. (1977) Narasin A (A28086A; Streptomyces aureofaciens 4-methyl-salinomyNRRL 5758, NRRL 8092 cin), Band D OCCOLOWITZ et al. (1976) KINASHI and OTAKE (1976) Nigericin HARNED et al. (1951) X-464 Polyetherin A Helixin C K-178 Azalomycin M Duamycin Noboritomycin A and B Streptomyces vio/aceoniger NRRL B1356 Streptomyces X-464 Streptomyces hygroscopicus E-749 (ATCC 21368) Streptomyces sp.

30 II ------. > Acetate __ 0---{> Malonate Acetate Methionine -* Methionine Fig. 8. a Scheme of biosynthesis of rifamycin ansa chain after condensation of malonate-methylmalonate. b Scheme of biosynthesis of streptovaricin ansa chain after condensation of malonate-methylmalonate from the aromatic nucleus, of eight methylmalonate and two malonate units (Fig, 8b). In fact, I- 13 C-propionate labels carbon atoms C-l, C-5, C-7, C-9, C-13, C-15, and C-19 whereas 2_ 13 C malonate enriches equally C-4 and C-18.

5 0 , The degradation reactions and products are shown in Scheme I 48 J. W. WESTLEY: C-12 bond, the site of this cleavage. This results in a (V): (VI) ratio of I: I (or 2:2) in the [2- and 3- I4 C]propionate experiments, but 3: I in the [l_14C]propionate case. The four propionate-derived C-methyls must be at C-4, ColO, C-12, and C-16 since the C-23 methyl is acetate-derived. Kuhn-Roth oxidation of the three [14C]butyrate-derived samples established that the butyrate units incorporated into (I) are only at the C-ethyl positions.

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