By Ronald Wetzel, Indu Kheterpal

The facility of polypeptides to shape then again folded, polymeric buildings comparable to amyloids and similar aggregates is being more and more well-known as an incredible new frontier in protein learn. This new quantity of Methods in Enzymology in addition to half B (volume 412) on Amyloid, Prions and different Protein Aggregates proceed within the culture of the 1st quantity (309) in containing special protocols and methodological insights, supplied by means of leaders within the box, into the newest equipment for investigating the buildings, mechanisms of formation, and organic actions of this crucial type of protein assemblies.

  • Presents targeted protocols
  • Includes troubleshooting tips
  • Provides assurance on structural biology, computational equipment, and biology

Show description

Read Online or Download Amyloid Prions and Other Protein Aggregates PDF

Best molecular biology books

Cell Mechanics

Mobile mechanics is the sphere of research that appears at how cells notice, regulate, and reply to the actual homes of the cellphone setting. Cells speak with one another via chemical and actual signs that are all in favour of a variety of method from embryogenesis and wound therapeutic to pathological stipulations akin to cancerous invasion.

Carotenoids and Retinoids

The presence of carotenoids within the vitamin and their position in human wellbeing and fitness has turn into a subject matter of unparalleled curiosity. The chapters during this publication symbolize an account of the knowledge offered at a contemporary workshop, mixed with numerous extra invited contributions to hide themes extra thoroughly which are presently on the leading edge of analysis.

Plant cytogenetics

Cytogenetics performs an immense position in knowing the chromosomal and genetic structure of plant species. Plant Cytogenetics, 3rd version follows the culture of its predecessors featuring theoretical and functional facets of plant cytogenetics. Chapters describe right dealing with of plant chromosomes, equipment in plant cytogenetics, mobilephone department, copy tools, chromosome nomenclature, karyotype research, chromosomal aberrations, genome research, transgenic vegetation, and cytogenetics in plant breeding.

Additional info for Amyloid Prions and Other Protein Aggregates

Sample text

Vonsattel, J. , and Aronin, N. (1997). Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990–1993. Donaldson, K. , Ching, K. , Tsai, C. , and Joazeiro, C. A. (2003). Ubiquitin‐mediated sequestration of normal cellular proteins into polyglutamine aggregates. Proc. Natl. Acad. Sci. USA 100, 8892–8897. Doss‐Pepe, E. , Stenroos, E. , Johnson, W. , and Madura, K. (2003). Ataxin‐3 interactions with rad23 and valosin‐containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin‐mediated proteolysis.

J. Biol. Chem. 270, 13842–13849. f Jackson‐Fisher, A. , and Pugh, B. F. (1999). A role for TBP dimerization in preventing unregulated gene expression. Mol. Cell 3, 717–727. , and Herr, W. (2002). A regulated two‐step mechanism of TBP binding to DNA: A solvent‐exposed surface of TBP inhibits TATA box recognition. Cell 108, 615–627. h Peterson, M. , Pugh, B. , and Tjian, R. (1990). Functional domains and upstream activation properties of cloned human TATA binding protein. Science 248, 1625–1630. i Kao, C.

Methods Enzymol. 309, 375–386. e Coleman, R. , Taggart, A. , Benjamin, L. , and Pugh, B. F. (1995). Dimerization of the TATA binding protein. J. Biol. Chem. 270, 13842–13849. f Jackson‐Fisher, A. , and Pugh, B. F. (1999). A role for TBP dimerization in preventing unregulated gene expression. Mol. Cell 3, 717–727. , and Herr, W. (2002). A regulated two‐step mechanism of TBP binding to DNA: A solvent‐exposed surface of TBP inhibits TATA box recognition. Cell 108, 615–627. h Peterson, M. , Pugh, B.

Download PDF sample

Rated 4.63 of 5 – based on 9 votes