By Moselio Schaechter (auth.), Kendric C. Smith (eds.)

The covalent attachment to deoxyribonucleic acid in vivo of a big variety of kinds of chemicals (both basic mobile ingredients reminiscent of proteins and amino acids, and in addition exogenous compounds comparable to medicines, cancer causing agents, and so on. ) were proven to exert profound results upon cells. 4 examine activi­ ties, previously thought of to be completely autonomous, relate to this challenge of nucleic acid adducts--(1) common covalent attachment of DNA to membranes, protein linkers in chromosomes, and so forth. ; (2) the jobs of radiation and chemical enhancement of DNA adduct formation in mobilephone killing and mutagenesis. (A comparable box is using identified cross-linking reactions to realize info on structural institutions in macromolecular complexes. ); (3) the relevance of DNA adducts to chemical and radiation carcinogenesis; (4) the rele­ vance of DNA adducts to the cross-linking thought of mobile getting older. (1) there are lots of examples of ordinary linkages among DNA and protein, e. g. , DNA-membrane attachment websites, protein linkers in chromosomes, amino acids covalently associated with DNA as a functionality of progress stipulations, and gene legislation by means of non-covalently sure proteins. A precis of information on usual adducts to DNA hence serves to introduce the topic of the radiation and chemical enhancement of DNA adduct formation. (2) long ago, radiation biology has been involved almost always with attempting to comprehend the radiation chemistry of purified DNA, and the organic results and service of those radiation-induced changes while produced in mobile DNA.

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Extra info for Aging, Carcinogenesis, and Radiation Biology: The Role of Nucleic Acid Addition Reactions

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Recently a number of investigators have attempted to verify this observation. , 1964; Sarfert and Venner, 1965; Olenick and Hahan, 1964; Berns and Thomas, 1965). Some, despite the consistency of this observation, feel that the amino acids are simply impurities difficult to remove and refer to their DNA preparations as having 11 less than 11 a certain arbitrary amount of amino acids. Nevertheless, the most striking aspect of these observations is the fact that no matter which solvents or precipitants are used, even when completely new procedures are introduced such as biphasic liquid-liquid extraction in which no opportunities for coprecipitation of impurities is given, a limiting value is reached; the same amount of amino acids are found (Rudin and Albertsson, 1967; Favre and Pettijohn, 1967).

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1975, Size and structure of a mammalian DNA determined by sedimentation and confirmed by viscoelastometry, Biophys. J. 15:205a. C. B. ), Plenum Press, New York (in press). , 1967, Rejoining of X-ray induced breaks in the DNA of leukaemia cells, Nature (London) 214:790-792. , 1970, On the size of the DNA in the mammalian chromosome: structural subunits, Biophys. J. 10:277-292. , 1962, Physicochemical changes produced in DNA after alkylation, Arch. Biochem. Biophys. 97:80-93. , 1960, The relationship between molecular weight and viscosity as a criterion of damage in DNA, Makromol.

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