By G. F. Rossi (auth.), Professor Jan Gybels, Professor Edward R. Hitchcock, Priv.-Doz. Christoph Ostertag, Professor Gian Franco Rossi, Professor Jean Siegfried, Professor Gabor Szikla (eds.)

Local interstitial radiation remedy of intrinsic and inaccessible mind tumors is faced with significant difficulties: 1. The tolerance of ordinary mind tissue, that is frequently thinking about neighborhood tumor irradiation, i.e. perifocal white subject edema and demyelinating results, is important. 2. information on radiation results of implanted radioactive resources on neoplastic tissue, i.e. facts at the radiosensitivity and at the biology of tumors, are nonetheless greatly unavailable. In medical perform the dose with which to accomplish a given quantity of tumor necrosis is approximately expected. This file bargains with the experimental findings of Iodine-125 and Iridium-I92 everlasting implants in fit and neoplastic mind tissue. Our personal experimental findings are correlated with experimental information on Yttnul11-l)O irradiation from the literature. The research is directed to gather information at the tolerance non-tumoral mind tissue and to aim to set up a dose-response courting. Morphologic adjustments within the puppy mind Following Interstitial Iodine-125 Irradiation Iodine-I25 seeds (manufactured through three M corporation, St. Paul, M. N.) with an job of 3.55 mCi have been completely implanted below stereotactic stipulations into the subcortical white topic of the gyrus coronalis of the left hemisphere in 6 beagle canines. One animal with a non-radioactive seed implanted lower than comparable operative stipulations served as a keep an eye on. The animals have been allowed to outlive 25, forty six, seventy one, ninety four, 248, 368 days, respectively, after the implantation. The regulate animal survived forty six days. an in depth description of the experimental technique is given somewhere else sixteen. 17.

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Extra info for Advances in Stereotactic and Functional Neurosurgery 6: Proceedings of the 6th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Rome 1983

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C. Associated Clinical Signs 1. Early: During the first 10 seconds, 10 patients (19 seizures) have bilateral blinking with or without a bilateral mydriasis. Only 3 patients (4 seizures) have visual hallucinations in color in the visual 51 Eye Movements and Occipital Seizures in Man field opposite the side of the discharge. Two patients had postural modifications of the controlateral upper limb, and an other had chewing activity. 2. Late: Simple and complex visual hallucinations as well as oro-alimentary and simple gestural "automatisms" were more frequent than at the beginning of the seizures.

J :. /. ... //. ·~. '/'" - fr "-\\ --..... --_. L ...... \ ABC Y' 5 \ 7 6 8 / 11 1//1 V G 0 . / / I-' \ -:1. V V ......... f /. : ... ; . "'"0. ··. . I . 1/ I . . \\ . Y \ 0/ I .. : 1 1\ . ..... ~ U . ----- - ) ···K . ~,.. --:... ~ 7 8 CACP 9 1'G \ 11 ~,~ ~ \ 12 ~\ ............ l.. -~ '-I.. 'oJ ~ " ,/ ~\ ~/ o C B A Fig. 1. Lateral projection of 157 electrodes (16 patients). L 83, R 74 3. There was a strict relationship between the type of the discharge and the modalities of the ocular deviation: when the discharge is fast, the eye movement is rapid and continuous; a discharge of slow, pseudorythmic spikes is related to a brisk, saccadic adversion.

Further EEG recordings, using sphenoidal electrodes are made during and after the PET studies. The EEG data is analysed both visually and by computer analysis for epileptiform sharp waves and spikes. Results 1. Normal Subjects All subjects reported that they remained awake throughout the study. Light and noise were subdued, but ear plugs or eye patchs were not used. Fig. 1 gives examples of FDG studies in normal subjects, illustrating the symmetry of rCMRGl between the two cerebral hemispheres.

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