By P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)

Since 1987 Acute Leukemias (AL) has on a regular basis pronounced at the cutting-edge within the swiftly growing to be, profitable and interesting box of biology and administration of those illnesses. during this quantity huge multicenter medical trials back shape the forged foundation for the research of leukemic mobilephone biology, the detection of biologic subgroups, their differential reaction to replacement therapy recommendations and the additional improvement of treatment. particularly, this quantity addresses mechanisms of chromosomal translocations and transcription components, risk-adapted therapy concepts, differentiation remedy, secondary AL, exact elements in older sufferers, and adoptive immunotherapy. in addition to the antileukemic techniques, supportive therapy with new antimicrobial components and development components is up to date. As a discussion board of globally actions within the box of AL this quantity comprises either exhaustive overviews on significant medical concerns and initial information and hypotheses no longer formerly published.

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Chronic myelomonocytic leukemia and esophageal cancer developed in a renal allograft recipient. Rinsho Ketsueki (Japanese Journal of Clinical Hematology), 34 (7): 842-846 , 1993. 24. Hand MF, Anderton JI.. Acute myleoid leukaemia following renal transplantation and previous Wilms_ tumour. Nephr Dialysis Transpl, 7 (7): 653, 1992. 25. Adler KR, Lempert N, Scharfman WB. Chronic granulocytic leukemia following successful renal transplantation. Cancer 41: 2206-2208, 1978. Molecular Cytogenetic Characterization ofa Critical Region in Bands 7q35-q36 Commonly Deleted inMalignant Myeloid Disorders K.

Experience with postt ransplant Iymphoproliferative disorders in solid organ transplant recipients. Clin Transpl6: 249-252, 1992. 13 9. Penn 1. Posttransplantation de novo tumors in liver allograft recip ients. Liver Transpl Surg 2 (1): 52-59 ,1996 . 10. Kinlen LJ. Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. Am J Med (1A): 44, 195. 11. Penn 1. Malignancy. Surg Clin N Am, 74 (5): 1247-1257,1994. 12. Penn 1. Posttransplant malignancies in ped iatric organ transplant recipients.

1996; Saha et al. 1995). To further delineate the role of these three genes (AFlO, CALM and MLL) in acute lymphoblastic and acute myeloid leukemia, we analyzed 10 patient samples (9 AML, 1 ALL) with cytogenetically identified t(l0;1l)(p1214;q13-2l) and well characterized morphology and immunophenotype. Material and Methods Patients samples Based on the cytogenetic data and the availability of material, 9 AML and 1 ALL with t(l0;1l)(p12-14;q14-2l) were collected from the major German cytogenetic centers (Table 1).

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